Nordic Biomarker is mainly an OEM supplier of reagents, but we are also proud to offer some of our reagents as complete CE-marked Nordic branded kits.
At Nordic Biomarker we are proud to call ourselves D-dimer nerds! As a supplier of reagents to OEM-partners around the world, using several different analyzers, we have developed three different kinds of D-dimer reagents.
Why is D-dimer testing valuable?
The main use of D-dimer testing is to reduce the costs and risks when diagnosing suspected cases of Venous Thromboembolism (VTE). In the past, before D-dimer testing was widely used in hospital laboratories, most patients with suspected VTE needed to be diagnosed with relatively expensive imaging techniques. Today, incorporating more specific laboratory tests for D-dimer, up to 50% of the suspected cases of VTE can be excluded without using any imaging techniques. This is not only healthcare money saved, but it also increases patient safety since some of the imaging techniques used are invasive.
Why do we use colours in the product names?
The difference between Nordic Biomarker’s three types of D-dimer reagents, is the size of latex particles used to produce them. Apart from that, all three are Latex Immunoassays (LIA) using immunoturbidimetry as detection principle. Also, all three reagents appear white, when looking at them in real life. Their names, Red, Green and Blue D-dimer are just a mnemonic trick to remember which wavelength they are designed for: red light has long wavelength, blue has short, and green is in the middle!
Free Protein S Reagents
Nordic’s two Free Protein S kits are latex immunoassays (LIA) for the quantitative determination of free Protein S (FPS) in human plasma.
Our kits only measure the free form of Protein S
Both Free Protein S kits consists of sub-micron sized polystyrene particles coupled to two different monoclonal antibodies specific for Protein S. This system is not sensitive to Protein S bound to C4b-binding protein (C4BP), and only reacts with free Protein S.
Why have we developed two different kits?
There are many different coagulation analyzers on the market, operating various different wavelengths.
Nordic Biomarker has designed two different kits to make this parameter available on most coagulation analyzers, regardless of the optical system and wavelength of light used.
Nordic Green FDP is a latex immunoassay intended for the quantitative determination of Fibrin(ogen) Degradation Products in human plasma. Green FDP is suitable for coagulation analyzers with optical channels in the wavelength range 500 – 650 nm.
Currently, Nordic Green FDP is only available as OEM-bulk. Please contact us if you are interested in samples for evaluation.
Degradation products from fibrin and fibrinogen
In contrast to Nordic’s D-dimer kits, who are sensitive for degradation products from cross-linked fibrin containing the D-dimer motif, the new FDP kit is also sensitive for other degradation products from both fibrinogen as well as non-cross linked fibrin. Degradation products from fibrin and fibrinogen, from the action of plasmin, are known as FDP. This is an important marker for monitoring the status of fibrinolytic disorders occurring in the cardiovascular system, in particular to diagnose and monitor the progress of Disseminated Intravascular Coagulation (DIC).
Nordic’s FDP reagent consists of sub-micron sized polystyrene particles coupled to two different monoclonal antibodies specific for FDP. When the reagent in Nordic FDP is exposed to a plasma sample containing FDP, the particles will agglutinate, giving rise to increased light-scattering. When exposed to the appropriate wavelength of light, the increase in measured turbidity, or light-scattering, is proportional to the amount of FDP in the sample. The linear measuring range depends on the performance of the coagulation analyzer used, but is typically in the 4 – 120 µg/mL range.
von Willebrand Disease (vWD) is the most common coagulation disorder in humans, affecting around 1% of the general population.
vWD is due to either qualitative or quantitative deficiencies of the circulatory protein von Willebrand Factor (vWF). For this reason, methods for determining both the concentration (antigenic = Ag) as well as the function (activity = Ac) of vWF are needed.
Nordic Biomarker is currently developing two different Latex Immunoassays (LIA) for vWF, one for antigenic determination and the other for measuring the activity of vWF in human plasma. Please contact us is if you are interested to participate and cooperate in the future evaluation of these products.
Calibrators and controls
Together with our various reagent kits, we also supply the auxiliary products needed to provide the correct assay results in the laboratory. This includes all calibrators, controls and buffers needed to make the measuring method complete.
We have control on our calibrators and controls!
All of our calibrators and controls have a clear traceability to reference systems or, when available, international standards. We also participate in external quality assessment programs as an extra check to ensure that there is no drift in the reference systems. As our OEM-client, all of these products are available in unlabeled bottles.