Nordic Biomarker’s FDP reagent is developed to measure a broader range of fibrin and fibrinogen degradation products (FDP). FDP is a generic name for all fragments formed during plasmin cleavage of fibrin and fibrinogen. The determination of fibrinogen degradation products has become a prevalent aid in the diagnosis of disseminated intravascular coagulation (DIC), pulmonary embolism (PE), deep vein thrombosis (DVT) and acute aortic dissection (AAD). The FDP assay is commonly used in some markets where the laboratories run the FDP assay in parallel with the D-Dimer assay.
Whereas plasmin degradation of fibrin occurs in presence of a fibrin clot, plasmin degradation of fibrinogen occurs during over activation of the coagulation system causing systemic fibrinolysis. During systemic fibrinolysis, seen in patients with DIC, activated plasmin cleaves circulating fibrinogen, rendering elevated levels of fibrinogen degradation products in the blood stream.