Nordic Biomarker is proud to offer the most complete and flexible portfolio of OEM-reagents for coagulation diagnostics on the market. Strengthen your brand name and expand your business by completing your portfolio with our high quality reagents.

Clotting assays

PT Quick

Nordic Biomarker’s PT Quick is a rabbit tissue-based reagent. The PT Quick reagent is easy to reconstitute, and calcium is already added to the reagent before lyophilisation. PT Quick is a single vial product calibrated against the most recent WHO thromboplastin standard, RBT/05, which is traceable to the first reference preparation of thromboplastins. The calibration assures low lot-to-lot variation and consequently results in reliable PT determination.

PT Owren

Nordic Biomarker’s PT Owren measures the prothrombin complex activity, based on the activity of the vitamin K-dependent coagulation factors; FII, FVII and FX, specifically. PT Owren can be measured days after the blood is drawn, while the degeneration of FV will start to affect PT Quick results after only a few hours.


Activated partial thromboplastin time (APTT) is a commonly used screening test for haemostatic defects in the intrinsic and common pathway of the coagulation cascade, as well as the contact activation system. Thus, FV, FVIII, FIX, FX, FXI, FXII, prekallikrein and high-molecular weight kininogen deficiencies can result in a prolonged APTT. Moreover, APTT is also suitable for monitoring heparin treatment.

Fib Clauss

Fib Clauss is a functional clotting assay used for quantification of fibrinogen in citrated plasma. Fib Clauss reagent utilises the Clauss technique, where a high concentration of thrombin is added to pre-diluted plasma and the clotting time is measured. The clotting time depends on the level of functional fibrinogen in the sample. Fib Clauss reagent has a large linear range, up to 8 g/L, limiting the number of re-analyses.

Thrombin Time

Thrombin Time (TT) reagent is designed to detect an impaired fibrin polymerisation process and presence of heparin. It can be used as a screening test for functional abnormalities of fibrinogen, and to detect the presence of heparin and/or thrombin inhibitors in citrated plasma. The assay measures the ability of exogenous thrombin to convert fibrinogen to fibrin, followed by fibrin polymerisation and clot detection. TT is a common clotting test used to detect fibrinogen abnormalities, and the presence of heparin and other thrombin inhibitors in human citrated plasma. Nordic Biomarker’s Thrombin Time has been designed for easy quality control and should only be used with normal controls.


PT DOAC is used for functional determination of the extrinsic pathway of the coagulation cascade in patients treated with direct oral anticoagulants (DOACs). A simple and rapid assay for functional determination of DOAC effect has been needed since the introduction of DOACs. A major drawback of using conventional coagulation tests for estimation of DOAC effect is the substantial variability in the sensitivity to DOACs amongst different reagents. Nordic Biomarker has taken this disadvantage into account in the development of PT DOAC. This novel prothrombin time (PT) method utilizes a concept already proven for warfarins. As a conventional PT determines the effect of warfarin and not the concentration, PT DOAC determines the effect of DOACs and not the concentration. Furthermore, only one reagent is needed to detect the effect of all the DOACs. The method is patented in Europe (EP31416347) and a world-wide patent (WO2015177293) is pending. We are currently looking for collaborators that are interested in working with us to evaluate the clinical usefulness of this For Research Use Only Product.

Immunologic assays


D-dimer is a clinically proved, high quality reagent for exclusion of deep vein thrombosis (DVT) and pulmonary embolisms (PE). The reagent has a low cut-off with a high sensitivity. The D-dimer suite includes two different products designed to match different measuring instruments, operating in the blue wavelength range (400–600 nm) or in the red wavelength range (600–800 nm). As there is excellent correlation between each product, any laboratory can standardise their D-dimer reporting across different platforms and receive comparable results regardless of instrument.

Free Protein S

Nordic Biomarker’s Free Protein S (FPS) is a latex immunoassay for the quantitative determination of free protein S in citrated plasma. Inherited and acquired protein S deficiency is an important risk factor for deep vein thrombosis (DVT), and pulmonary embolism (PE). Measurements of free protein S can detect more subtypes of protein S deficiency than measurements of total protein S and has therefore become an important tool in clinical thrombosis investigations MRX FPS consists of sub-micron sized polystyrene particles coupled to two different monoclonal antibodies specific for protein S. This system is not sensitive to protein S bound to C4BP, and therefore only reacts with free protein S.


FDP is used primarily in Asia as a complement to D-dimer for monitoring fibrinolysis

vWF Antigen

Green vWF Antigen is a latex immunoassay for quantitative determination of vWF Antigen in citrated human plasma which can be used as an aid in diagnosis of von Willebrand disease (vWD). vWD is the most common hereditary bleeding disorder and is caused by either a quantitative or a qualitative defect of vWF.

Chromogenic assays


Nordic Biomarker’s Antithrombin (AT) is a liquid, functional, chromogenic assay based on the inhibition of FXa in the presence of heparin. The chromogenic AT assay measures the AT activity (functional AT) by a two-stage method as follows: An excess of FXa is added to the citrated plasma sample pre-diluted with saline and in the presence of heparin. The residual FXa cleaves the peptide linked to the chromogenic FXa substrate, which results in the release of free p-nitroaniline (pNA). The amount of released pNA is measured at 405 nm and the absorbance is inversely proportional to the AT activity in the patient plasma, expressed as IU/mL or %.

Protein C

Nordic Biomarker's Protein C is a chromogenic test for quantitative determination of Protein C activity in citrated human plasma which can be used as an aid in diagnosis of Protein C deficiency. Protein C deficiencies, hereditary and/or acquired, increases the risk for developing thromboembolic disease.


Routine controls

Nordic Biomarker's Routine Controls features a high stability together with the unique ability of adding many parameters in one control. The Routine Controls is suitable for the routine laboratory and are available in normal and abnormal levels.

Specialty controls

Nordic Biomarker's Specialty Controls features a high stability together with the unique ability of adding many parameters in one control. The Specialty Controls is suitable for the specialty laboratory and are available in normal and abnormal levels.

FDP controls

FDP is a generic name for all fragments formed during plasmin cleavage of fibrin and fibrinogen. FDP Clear Controls consists of human-derived fibrin and fibrinogen degradation products. Intended for quality control of Green FDP reagent.

Buffers, solutions and calibrators

Nordic Biomarker offer all necessary buffers, solutions and calibrators needed to run tests with our reagents on OEM-basis.